Study Links a History of AKI With Pre-Eclampsia, Adverse Fetal Outcomes

December 23, 2016

WASHINGTON, DC -- December 23, 2016 -- A past episode of acute kidney injury (AKI), despite return to normal kidney function before pregnancy, was linked to adverse pregnancy outcomes, according to a study published early online and appearing in an upcoming print issue of the Journal of the American Society of Nephrology (JASN).

Jessica Sheehan Tangren, MD, Massachusetts General Hospital, Boston, Massachusetts, and colleagues examined whether a history of recovered AKI (r-AKI) increases the risk of later problems during pregnancy.

The researchers retrospectively studied all women who delivered infants between 1998 and 2007 at Massachusetts General Hospital (105 women with r-AKI and 24,640 women without kidney disease).

Women with r-AKI had an increased rate of pre-eclampsia compared with controls (23% vs 4%).

In addition, infants of women with r-AKI were born earlier than infants of controls (average 37.6 vs 39.2 weeks), with increased rates of small-for-gestational-age births (15% vs 8%).

After adjusting for various patient factors, r-AKI was linked with a 5.9-times increased risk for preeclampsia and a 2.4-times increased risk for adverse fetal outcomes.

“We believe that this study highlights an important finding that will be useful for medical providers caring for reproductive-age women,” said Dr. Tangren. “Our goal in future studies is to address why women with a history of AKI are at higher risk for pregnancy complications and to identify strategies to lower their risk. Furthermore, we hypothesise that the varying rates of pre-eclampsia reported worldwide may be explained, at least partially, by our study.”

SOURCE: American Society of Nephrology

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