Can Slow Walking Speed in Elderly Signal Alzheimer’s Disease Hallmarks?

MINNEAPOLIS -- December 2, 2015 -- How fast elderly people walk may be related to the amount of amyloid they have built up in their brains, even if they don’t yet have symptoms of Alzheimer’s disease, according to a study published in the December 2, 2015, online issue of the journal Neurology.

The study involved 128 people with an average age of 76 years who did not have dementia but were considered at high risk for developing it because they had some concerns about their memory. The participants had positron emission tomography (PET) scans of their brains to measure amyloid plaques in the brain. Of the participants, 48% had a level of amyloid often associated with dementia.

Participants were also tested on thinking and memory skills and how well they could complete everyday activities. A total of 46% of the participants had mild cognitive impairment (MCI).

Walking speed was measured with a standard test that times people on how fast they can walk about 13 feet at their usual pace. The average walking speed was 3.48 feet per second. All but 2 of the participants tested in the normal range of walking speed.

The researchers found an association between slow walking speed and amyloid in several areas of the brain, including the putamen, a key region involved in motor function.

The researchers compared how fast people walked both with and without taking into account the amount of amyloid and found that the amyloid level accounted for up to 9% of the difference in walking speed.

The relationship between amyloid levels and walking speed did not change when researchers took into account age, education level, or amount of memory problems.

“It’s possible that having subtle walking disturbances in addition to memory concerns may signal Alzheimer’s disease, even before people show any clinical symptoms,” said Natalia del Campo, PhD, University Hospital Toulouse, Toulouse, France.

Dr. del Campo noted that the study looked only at a snapshot in time and does not prove that amyloid plaques cause the slowdown in walking speed; it shows the association. She also noted there are many other causes of slow walking in older adults.

SOURCE: American Academy of Neurology
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