June 28, 2016

Escitalopram Does Not Reduce Hospitalisation, Death, or Improve Mood for Heart Failure Patients With Depression

PARSIPPANY, NJ -- June 28, 2016 -- In a study appearing in the JAMA, Christiane E. Angermann, MD, University Hospital Wurzburg, Germany, and colleagues examined whether 24 months of treatment with the antidepressant escitalopram would improve mortality, illness, and mood in patients with chronic heart failure and depression.

Previous meta-analysis indicates that depression prevalence in patients with heart failure is 10% to 40%, depending on disease severity. Depression has been shown to be an independent predictor of mortality and rehospitalisation in patients with heart failure, with incidence rates increasing in parallel with depression severity. Long-term efficacy and safety of selective serotonin reuptake inhibitors (SSRIs), which are widely used to treat depression, is unknown for patients with heart failure and depression.

For this study, 372 patients with chronic heart failure with reduced ejection fraction and depression were randomly assigned to receive escitalopram or matching placebo in addition to optimal heart failure therapy. During a median participation time of 18.4 months (n = 185) for the escitalopram group and 18.7 months (n = 187) for the placebo group, the primary outcome of death or hospitalisation occurred in 116 (63%) patients and 119 (64%) patients, respectively. There was no significant improvement on a measure of depression for patients in the escitalopram group.

“These findings do not support the use of escitalopram in patients with chronic systolic heart failure and depression,” the authors write.

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