Low Birth Weight Babies at Higher Risk for Mental Health Problems Later in Life

WASHINGTON, DC -- February 13, 2017 -- Babies born with extremely low birth weight are not only at risk for physical problems but are also more likely to experience mental health problems later in life, according to an analysis of research conducted over nearly 30 years.

“Our findings provide evidence that individuals born at extremely low birth weight are at higher overall risk for psychological difficulties than their normal birth weight peers,” said Karen Mathewson, PhD, McMaster University, Montreal, Quebec. “These difficulties most frequently involve attention, anxiety-related and social problems.”

For the study, published in the journal Psychological Bulletin, the researchers conducted a meta-analysis using 41 studies that followed 2,712 individuals who were extremely low birth weight babies and 11,127 who were normal birth weight babies. The studies took place over a 26-year period (1990-2016) in 12 different countries, including the United States and Canada.

Extremely low birth weight babies were found to be at increased risk for particular mental health problems, beginning in childhood and extending at least into their 30s. As children, they were significantly more likely to have attention-deficit/hyperactivity disorder (ADHD) in almost every study included in the review. Adolescents were also at greater risk for ADHD and social problems. Adults born with extremely low birth weight reported significantly higher levels of anxiety, depression and shyness, as well as significantly lower levels of social functioning.

These risks did not seem to vary according to where or when extremely low birth weight survivors were born, or whether they had significant neurosensory impairments, such as cerebral palsy or blindness. All of the studies were from developed countries from North America, Europe or Australia.

Dr. Mathewson believes these findings may stem from biological responses of the infant to difficult prenatal conditions and postnatal stresses following early birth.

“The consistency of the findings across geographical regions suggests that these attentional, behavioural, and social outcomes may be contributed to by developmentally programmed, biological factors,” she said.

Even though the risk for mental health problems in extremely low birth weight survivors is increased compared with normal birth weight individuals, many will not develop mental disorders at all. However, the effect sizes for ADHD, social problems, and internalising disorders were moderate-to-large in extremely low birth weight children, and remained moderate in extremely low birth weight adolescents. Moderate effects of birth weight status suggest that group differences in the risk for these mental health problems can be significant.

The findings point to the need to continue to provide services to these individuals throughout their lives.

“It is important that families and health care providers be aware of the potential for early-emerging mental health problems in extremely low birth weight survivors, and that some of these individuals may not grow out of these problems as they get older,” said Dr. Mathewson. “As a result, it is essential that appropriate treatment be made available to those who require it as early in life as possible.”

SOURCE: American Psychological Association
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