Recurrent Depression, Use of Antidepressants Associated With Lower Bone Density in Men
Päivi Rauma, University of Eastern Finland, Joensuu, Finland, analysed data from the Geelong Osteoporosis Study (GOS) -- a large, ongoing, population-based osteoporosis study carried out in the Barwon Health Hospital, Geelong, Australia.
Between 2006 and 2011, 928 men aged 24 to 98 years completed a comprehensive questionnaire and had bone mineral density (BMD) assessments at the forearm, spine, total hip, and total body. MDD was identified using a structured clinical interview. Multivariate model was adjusted for lifestyle, medications and other confounding factors.
Of the study population, 90% had a single MDD episode, and 5% had suffered from recurrent MDD. Furthermore, 7% of the study participants reported the use of antidepressants at the time of assessment.
Recurrent MDD was associated with lower BMD at the forearm and total body (-6.5% and -2.5%, respectively), compared with men with no history of MDD, while single MDD episodes were associated with higher BMD at the total hip (+3.4%).
Antidepressant use was associated with lower BMD only in lower-weight men and varied across the bone sites. For example, the use of antidepressants was associated with reduced bone density in the hip in men weighing <110 kg. However, in the forearm, the association of anti-depressants with reduced bone density was not observed in men until their body weight was <75 kg.
According to the study, recurrent major depression may increase the risk of osteoporosis in men. Furthermore, the use of antidepressants should be taken into account as a potential risk factor of osteoporosis especially in men with a low body weight.
SOURCE: University of Eastern Finland
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