Study Finds Link Between Diet Drinks, Risk of Dementia and Stroke

BOSTON -- April 20, 2017 -- Data from the Framingham Heart Study (FHS) has shown that people who more frequently consume sugary beverages such as sodas and fruit juices are more likely to have poorer memory, smaller overall brain volumes, and smaller hippocampal volumes.

Researchers also found that people who drank diet soda daily were almost 3 times as likely to develop stroke and dementia when compared with those who did not consume diet soda.

These findings appear separately in the journals Alzheimer’s & Dementia and the journal Stroke.

“Our findings indicate an association between higher sugary beverage intake and brain atrophy, including lower brain volume and poorer memory,” said Matthew Pase, PhD, Boston University School of Medicine (BUSM), Boston, Massachusetts.

“We also found that people drinking diet soda daily were almost 3 times as likely to develop stroke and dementia,” he said. “This included a higher risk of ischaemic stroke, where blood vessels in the brain become obstructed and Alzheimer’s disease dementia.”

Excess sugar is known to have adverse effects on health. Diet soft drinks are often touted as a healthier alternative to regular soda. However, both sugar and artificially-sweetened beverage consumption has been linked to cardiometabolic risk factors, which increases the risk of cerebrovascular disease and dementia.

In these studies approximately 4,000 participants over the age of 30 from the community-based FHS were examined using magnetic resonance imaging (MRI) and cognitive testing to measure the relationship between beverage intake and brain volumes as well as thinking and memory. The researchers then monitored 2,888 participants aged 45 years and over for the development of a stroke and 1,484 participants aged 60 years and older for dementia for 10 years.

The researchers pointed out that pre-existing conditions such as cardiovascular disease, diabetes, and high blood pressure did not completely explain their findings. For example, people who more frequently consumed diet soda were also more likely to be diabetic, which is thought to increase the risk of dementia. However, even after excluding diabetics from the study, diet soda consumption was still associated with the risk of dementia.

Although the researchers suggest that people should be cautious about regularly consuming either diet sodas or sugary beverages, it is premature to say their observations represent cause and effect. Future studies are needed to test whether giving people artificial sweeteners causes adverse effects on the brain.

SOURCE: Boston University Medical Center
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